This prospective, double-blind, randomized controlled trial was designed to evaluate the efficacy of a culture temperature of 36.5°C versus 37°C on human embryo development in vitro . A total of 412 women undergoing IVF were randomized to two groups: the oocytes and embryos of the interventiongroupwereculturedat36.5°C;thoseofthecontrolgroupwereculturedat37°C.Althoughnosignificanteffectofculturetemperaturewasobserved onpregnancyorimplantationrates,differenceswerefoundinembryodevelopment.Embryocultureat36.5°Cwasassociatedwithasignificantlyhigher cleavage rate (OR 1.6, 95% CI 1.03 to 2.51), but a lower fertilization ...
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