Diallyl disulfide, from garlic oil, synthesizes human colonic adenocarcinoma cell line (Caco-2) to TNF-alpha mediated apoptosis through up-regulation of membrane FAS levels
Abstract: Colon cancer cells resistance to apoptosis inducing factors, particularly those working through the extrinsic apoptotic rout, such as Tumour necrosis factor alpha (TNF-α), may due to that these cells lack of the presence of FAS receptor on their membrane, to which TNF-α binds and causes the recruitment of caspase-8 and other caspases cascade required in apoptotic cell death. In ... Read more