Solvent Effects on The reactivity Trends of some Coumarin Derivatives
Kinetic results, rate laws and reaction mechanisms were established for the base hydrolysis of 7-hydroxycoumarin (HC), 7-hydroxycoumarin-4-acetic acid (HCA), 6-nitrocoumarin (NC), 6-nitrocoumarin-3-carboxylic acid (NCC), 7-dimethylamino-4-methylcoumarin (DMAC), 7-diethylamino-4-methylcoumarin (DEAC) and coumalic acid (COU) in aqueous solution, water-methanol and water-acetone mixtures. The kinetics of the base hydrolysis followed a rate law with kobs= k2[OH-] for all coumarin derivatives under study except 6-nitrocoumarin-3-carboxylic ... Read more