Synthesis and Anti-inflammatory Study of Novel N-substituted Hydro-acridine-1,8-diones and Bis-hexahydroacridine-1,8-dione Derivatives
We report in this study the synthesis of some new N-substituted hexahydro- acridine-1,8-dione compounds including some new N- 2-hydroxypropylhexahydro- acridine-1,8-diones and their tosylatedoctahydro-acridine-1,8-dione derivatives in addition to some bis-hexahydroacridine-1,8-diones via a one pot reaction technique. Moreover,in vivo anti-inflammatory evaluation for some newly synthesized compounds has been investigated. The highly alkylated bis-hydroacridine-1,8-dione 5f showed a higher anti- inflammatory potency more than ... Read more