hassan_elalaf

Hassan Mohamed Hassan Ali Elalaf

Lecturer - Lecturer - Physiology Dept. - Faculty of Medicine

Faculty of medicine

Address: Egypt- Sohag - Sohag city - ZIP Code: 82519

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Publications Which contain the keyword: lactate dehydrogenase


Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
3-Bromopyruvate (3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase (LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells (oxidative stress effect) and competes with the LDH substrates pyruvate ... Read more

Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study
3-Bromopyruvate (3BP) is a new, promising anticancer alkylating agent with several notable functions. In addition to inhibiting key glycolysis enzymes including hexokinase II and lactate dehydrogenase (LDH), 3BP also selectively inhibits mitochondrial oxidative phosphorylation, angiogenesis, and energy production in cancer cells. Moreover, 3BP induces hydrogen peroxide generation in cancer cells (oxidative stress effect) and competes with the LDH substrates pyruvate ... Read more

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