ahmedabudief

Prof. Ahmed Mohamed Abu-Dief

Professor - Professor of Physical and Inorganic Chemistry

Faculty of science

Address: Behind hospital of Sohag University - Ali Ebn Abi Taleb Street

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Publications Which contain the keyword: Colorectal cancer

Novel Green Biosynthesis of 5-Fluorouracil Chromium Nanoparticles Using Harpullia Pendula Extract for Treatment of Colorectal Cancer

2021-02-06 02:46:42 Keywords Colorectal cancer,
Novel Green Biosynthesis of 5-Fluorouracil Chromium Nanoparticles Using Harpullia Pendula Extract for Treatment of Colorectal Cancer
Colorectal cancer (CRC) is the third major cause of morbidity and mortality worldwide. Hence, many strategies and approaches have been widely developed for cancer treatment. This work prepared and evaluated the antitumor activity of 5-Flurouracil (5-Fu) loaded chromium nanoparticles (5-FuCrNPs). The green biosynthesis approach using Harpullia (H) pendula aqueous extract was conducted for CrNPs preparation that was further loaded with ... Read more

Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.

2019-02-08 01:08:26 Keywords Colorectal cancer, Ceramide, P53, tamoxifen, P-glycoprotein,
Tamoxifen magnifies therapeutic impact of ceramide in human colorectal cancer cells independent of p53.
Poor prognosis in patients with later stage colorectal cancer (CRC) necessitates the search for new treatment strategies. Ceramide, because of its role in orchestrating death cascades in cancer cells, is a versatile alternative. Ceramide can be generated by exposure to chemotherapy or ionizing radiation, or it can be administered in the form of short-chain analogs (C6-ceramide). Because intracellular P-glycoprotein (P-gp) ... Read more

Markers defining colorectal adenoma-carcinoma progression: a computerized image analysis protocol

2018-10-23 20:22:05 Keywords Colorectal cancer, adenoma, Carcinoma, , Bcl-2, Bax , P53, Ki-67, , ApopTag, , β-Catenin,
Markers defining colorectal adenoma-carcinoma progression: a computerized image analysis protocol
ABSTRACT: The vast majority of colorectal carcinoma are widely believed to arise from polypoid adenomas. The apoptotic related genes that have been most consistently characterized in colonic cancer are bcl-2, bax, and p53. Studying the expression of these genes in adenoma carcinoma sequence will be of great value in producing the clinical behavior of benign tumors. Loss of contact inhibition ... Read more

Association of Paraoxonase-1(Q192R and L55M) Gene Polymorphisms and Activity with Colorectal Cancer and Effect of Surgical Intervention

2018-10-12 08:32:24 Keywords Q192R and L55M gene polymorphi, paraoxonase-1, Colorectal cancer,
Association of Paraoxonase-1(Q192R and L55M) Gene Polymorphisms and Activity with Colorectal Cancer and Effect of Surgical Intervention
Background: Colorectal cancer (CRC) is a leading cause of cancer-related death. Oxidative DNA damage may contribute to cancer risk and the antioxidant paraoxonase is one endogenous free radical scavenger in the human body which could therefore exert an influeence. Purpose: Aim of this study was to determine the role of serum arylesterase (ARE) and paraoxonase 1(PON1) activities in CRC patients ... Read more

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