ABSTRACT
BACKGROUND: Diabetes mellitus (DM), especially type 2, represents one of the
most important health problems worldwide and, according to recent estimations, it is
likely to worsen to critical levels in the next decades, with the great concern that this
disease is rising rapidly in younger population groups, including children and
adolescents. Oxidative stress is an important factor in the etiology and pathogenesis of
diabetes mellitus. Intercellular adhesion molecule-1: Intercellular adhesion molecule-1 (ICAM-1), also known as CD54, is an endothelial and leukocyte associated
transmembrane protein with relevance in stabilizing cell-cell interactions and
facilitating leukocyte endothelial transmigration. It is constitutively present in the
membranes of leukocytes and endothelial cells; upon cytokine stimulation, the
concentrations greatly increase. ICAM-1 ligation produces pro-inflammatory effects
such as inflammatory leukocyte recruitment by signaling through cascades involving
anumber ofkinases.
AIM OF THE WORK: In this study, we attempt torelationship between sICAM-1
(intercellular adhesion molecule-1) and diabetic nephropathy as an important marker
in inflammation, immune responses and in intracellular signaling events. we
determined plasma concentration of ICAM-l, serum malondialdehyde (MDA),
superoxide dismutase (SOD), Serum nitric oxide (NO) as a marker for endothelial
activation among type- 2 diabetic patients with or without nephropathy and oxidative
stress as a marker (as tool in early diagnosis of nephropathy as major diabetic
complications) also to explore the relationship between plasma level of ICAM-l and
insulin resistance in thestudied patients.
PATIENTS AND METHODS: This study carried out on 100 male individuals.
Their age ranged from 25- 60 years. They were classified as follows:Control group:
30 apparently healthy adult males. Patients groups: 70 patients suffering from type 2
diabetes mellitus, Patients were subdivided into two groups. Gr oup I:35 patients with
type 2 diabetes mellitus with normal albuminuria without complications.Gr oup II:35
patients with type 2 diabetes mellitus with nephropathy.
RESULTS:This study has found astrong relationship between sICAM-1
(intercellular adhesion molecule-1) and diabetic nephropathy. Ithas been shown that
inflammation has a role in thedevelopmentofdiabeticnephropathy, so sICAM-1 may