Background: DCIS is a malignant proliferation of mammary ductal epithelial cells without invasion beyond the basement membrane. Bcl-2, bax, bcl-xl and p53 are implicated in regulation of apoptosis. This study aimed to clarify the role of these gene products in DCIC. Materials and Methods: Immunohistochemical staining of 13 cases of DCIS with bcl-2, bax, bcl-xl and p53 was performed. Results: DCIS was graded into; 42% of low, 16% of intermediate, and 42% of high grade cases. P53 was negative in all low grades, positive in 66.7% intermediate grade, and in all high grade DCIS. Bcl-2 was positive in all DCIS with variable intensities. Bax was positive in 80% of low grade, 100% of intermediate grade, and in 100% of high grade DCIS. Bcl-xl was positive in 80% of low grade, and in all intermediate and high grade DCIS. P53 was inversely correlated with bcl-2 expression in DCIS (p<0.02). Insignificant positive correlation was present between p53 and bax expression and between p53 and bcl-xl expression in DCIS. An inverse correlation was present between bcl-2 and bcl-xl expression and between bcl-2 and bax expression in DCIS (p<0.01 for each). Positive correlation was present between bax and bcl-xl expression (p<0.000) in DCIS. Conclusions: p53 mutation is an early event in the evolution of breast cancer and its expression correlates with high grade lesions. Strong positive correlation between bax and bcl-xl, but the prognostic value of bcl-2 protein family in DCIC is still in need to more studies to be clarified