Shortage of irrigation water sources in Egypt brings out the issue of managing all the available water resources and to re-use the non-conventional water resources such as agricultural drainage water. In this study, treatment of agricultural drainage water by adsorption onto kaolinite or kaolinite-humic complex was carried out by using fixed bed column model. Total Organic Carbon, heavy metals, EC, pH, major cations and anions were determined before and after treatment process. Agricultural drainage water purification occurred with flow rate of 70 ml/hour for each 10 g of adsorbent to treat one liter. The results showed that the kaolinite-humic complex was better in treatment of agricultural drainage water than kaolinite. Pots experiment was conducted to study the influence of irrigation with treated and non-treated agricultural drainage water on some Jew's Mallow plant propertiesand soil’s chemical and physical properties. Plant and soil analysis showed great deterioration changes in plant and soil properties due to irrigation with treated agricultural drainage water. The results showed that drainage water treatment with modified clay hada significant reduction of total dissolved solids, heavy metals and organic contaminants which in turn enhanced chemical properties of treated agricultural drainage water as well as growth and health features of plants.