Abstract
Background: post menopausal period is a critical period for each female. How to
minimize the complications of this period is a matter of major concern. Materials and
Methods: 40 females' albino rates were included in this study; they were divided into
four equal groups. G1: Sham ovariectomized group, G2: ovariectomized group receiving
vehicle (Ve) 1mg/kg/day for 7 weeks intraperitoneal injection (Ip) after 7 weeks from
ovariectomy. G3: ovariectomized group receiving alendronat 0.1mg/kg/day for 7 weeks
(Ip) after 7 weeks from ovariectomy.G4: ovariectomized group receiving Oxytocin
0.1mg/kg/day for 7 weeks (Ip) after 7 weeks from ovariectomy. Serum level of (Alkaline
phosphatase, Oxytocin) was determined, Body Mass Density (BMD) was measured by
(DEXA), also a histological examination of the femur and tibia was done. Results:
Marked increase in serum levels of ALP and marked decrease of serum Oxytocin in G2
compared to G1 associated with picture of osteoporosis. Marked decrease of serum ALP
with improvement in osteoporotic picture in both G3 and G4.Conclusion: Treatment by
either alendronat or oxytocin (G3 and G4) improves the osteoporotic condition with
better improvement by Oxytocin