1-Aryl(hetaryl)(3-dimethylamino)propenones, ethoxymethylene and 2-dimethylaminomethylene derivatives of 1,3-dicarbonyles in the synthesis of N-(pyrimidin-2-yl)cyanamides

The method of synthesis of N-(pyrimidin-2-yl)cyanamides (N-(4-R-pyrimidin-2-yl), N-(5,6,7,8-tetrahydroquinazolin-2-yl)-, N-(5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl)-, N-(6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-yl)-, N-(5-acetyl-4-methylpyrimidin-2-yl)-, N-(5-R’-6-oxo-1,6-dihydropyrimidin-2-yl)- and N-(5-methoxycarbonyl-4-methylpyrimidin-2-yl)cyanamides) based on interaction of 1-R-(3-dimethylamino)propenones, 2-ethoxymethylene or 2-dimethylaminomethylene derivatives of 1,3-dicarbonyl compounds with inexpensive commercially available cyanoguanidine has been designed.