Back
gro
und
:
Hep
a
titis C v
i
ru
s,
h
a
s b
e
en
asso
ciated
with
a wid
e
v
a
riety of ex
trah
ep
atic
man
i
festatio
n
s
(EHM
) i
n
t
h
e
nat
u
ral
hi
st
or
y
of
t
h
e di
sea
s
e. Li
che
n
pl
a
nus
(L
P)
has
al
so bee
n
rep
o
r
t
e
d i
n
ass
o
ci
at
i
on
wi
t
h
t
h
e
h
e
p
a
titis C
v
i
ru
s. Obj
ectiv
e i
s
to
d
e
term
in
e th
e freq
u
e
n
c
y
o
f
HC
V i
n
p
a
tien
t
s
with
LP i
n
Soh
a
g
Un
i
v
ersity Hosp
ital.
Patien
t
s and
meth
od
s: Th
e st
ud
y was carried
o
u
t
in
Soh
a
g
Un
iv
ersity Ho
spital in
Cl
in
ical
Path
o
l
o
g
y
Departm
e
n
t
an
d
Derm
at
ol
ogy
Vene
re
ol
o
g
y
Depa
rt
m
e
nt
from
Oct
ober 2
0
0
9
t
o
A
p
ri
l
201
0,
on
70
pa
t
i
e
nt
s wi
t
h
LP
(3
4 m
a
l
e
s, 36
fem
a
l
e
s) t
h
ei
r
age ra
nge
d f
r
o
m
25 t
o
80 y
e
a
r
s ol
d
,
an
d 2
0
pat
i
e
nt
s (1
1 m
a
l
e
s, 9 fem
a
l
e
s) t
h
ei
r age ra
n
g
ed
fr
om
22 t
o
70 y
ears
ol
d a
s
a cont
r
o
l
gr
ou
p wi
t
h
ot
he
r derm
at
ol
ogi
c
a
l
m
a
ni
fest
at
i
ons. Pat
i
e
nt
s w
e
re recr
ui
t
e
d f
r
om
t
h
e out
pat
i
e
nt
cl
i
n
i
c
of
derm
at
ol
og
y
depa
rt
m
e
nt
, ful
l
hi
st
ory
,
cl
i
n
i
cal
exam
i
n
at
i
on,
bi
o
p
sy
i
n
som
e
cases t
o
co
n
f
i
r
m
t
h
e
di
ag
no
si
s of L
P
and l
a
b
o
r
at
o
r
y
i
nvest
i
g
at
i
o
ns f
o
r a
n
t
i
-
HC
V
d
e
tection
,
liv
er fun
c
tio
n
tests were don
e.
Resu
lts: Th
ere
was i
n
si
gni
fi
ca
nt
di
f
f
ere
n
ce b
e
t
w
een L
P
g
r
o
up a
n
d t
h
e c
o
n
t
ro
l gr
oup
r
e
g
a
r
d
i
n
g
the ag
e
or
th
e sex
(p
= 0.17
6)
. Th
ere
was a hi
g
h
l
y
si
gni
fi
ca
nt
i
n
cr
ease i
n
HC
V i
n
fect
i
o
n bet
w
e
e
n LP g
r
o
u
p
(
p
= 0.
00
0)
, a si
gni
fi
ca
nt
i
n
cr
ease i
n
HC
V
i
n
fect
i
o
n am
on
g t
h
e
ol
d a
g
e
pat
i
e
nt
s (
p
=
0
.
00
8
)
wa
s f
o
un
d,
HC
V
i
n
fect
i
o
n
an
d
d
u
rat
i
o
n
of
LP s
h
owe
d
a si
gni
fi
cant
correlation (p = 0.022), T
h
ere was an
increase in aspartate a
m
inotra
ns
fera
se (AST) in
acten
ic LP p
a
tien
t
s and
m
u
cous LP
pat
i
e
nt
s com
p
are
d
wi
t
h
t
h
ose
o
f
cl
assi
c t
y
pe
(
p
=
0.
02
8
)
.C
o
n
cl
usi
on:
A
p
o
ssi
bl
e rel
a
t
i
o
ns
hi
p
bet
w
een
LP an
d HC
V, t
h
u
s
, it seem
s th
at th
e
HC
V an
tib
od
y test is
n
ecessarily requ
ired
for LP p
a
tien
t
s.