Abstract Background: Histopathological differentiation between BCH and HGPIN in prostatic
needle biopsies is a diagnostic challenge. The gold standard for detection of HGPIN and BCH is
histopathological examination; however subjectivity in interpretation and tiny volume of obtained
tissue hamper reliable diagnosis.
Aims: The aim of this study was to assess usefulness of using the p63 and p504s to solve this problem.
Although the use of p63 and p504s is now well established in differentiation between preneoplastic
and neoplastic prostatic lesions, their usefulness in tiny tissue material is, however, not fully