Autoimmune diseases have common properties characterized by abnormal blood chemistry with high serum autoimmune
antibodies, and inflammatory mediators. Those causative pathological substances (CPS) cannot be excreted by physiological
mechanisms. Current treatments for autoimmune diseases involve steroids, cytotoxic drugs, plasmapheresis and monoclonal
antibodies. Wet cupping therapy (WCT) of prophetic medicine is called Al-hijamah that treats numerous diseases having
different etiology and pathogenesis via a pressure-dependent and size-dependent non-specific filtration then excretion of CPS
causing clearance of blood and interstitial fluids. Al-hijamah clears blood passing through the fenestrated skin capillaries.
Medical bases of Al-hijamah were reported in the evidence-based Taibah mechanism (Taibah theory). Al-hijamah was reported
to be an excellent treatment for rheumatoid arthritis that improved patients’ blood chemistry and induced significant clinical
improvement and pharmacological potentiation. Al-hijamah improved the natural immunity and suppressed the pathological
immunity through decreasing the serum level of autoantibodies, inflammatory mediators, and serum ferritin (a key player in
autoimmunity). Al-hijamah reduced significantly pain severity, number of swollen joints and disease activity with no significant
side effects. Main steps of Al-hijamah are skin suction (cupping), scarification (sharatmihjam in Arabic) and second suction
(triple S technique) that is better therapeutically than the traditional WCT (double S technique). Whenever an excess noxious
substance is to be removed from patients' blood and interstitial fluids, Al-hijamah is indicated.Shartatmihjam is a curative
treatment in prophetic teachings according to the prophetic hadeeth: "Cure is in three: in shartatmihjam, oral honey and
cauterization. I do not recommend my nation to cauterize".Al-hijamah may have better therapeutic benefits than plasmapheresis.
Al-hijamah may be promising in treating autoimmune diseases as a sole treatment or adjuvant treatment.