The present work presents the immunological aspects of schistosomes discussing the different host defense strategies against infection which might be of atmost importance in our understanding and evaluating the previous attempts conducted mainly in the second half of the last century to attain the elusive goal of a schistosome vaccine as well as the recent trials to realize the humanity dream of a reliable anti-schistosome vaccine foundation, Moreover, the present workers' comments on different vaccine candidates (shown in bold phrases) as well as recommendations for making this dream comes true.