Introduction: Aspirin (Acetyl salicylic acid) is widely used as anti-inflammatory, analgesic drug and in the prevention of cardiovascular diseases. Aspirin (ASA) is known for its common effect in causing gastric mucosal injury. The miswak is a natural toothbrush made from the twigs of the Salvadora persica (Salvadoraceae). S. persica possesses significant anti-inflammatory and antiulcer activity. Aim of the Work: To investigate the effects of aspirin with or without Salvadora persica for 2 weeks on fundic mucosa of adult female albino rats through histological examination by light and scanning electron microscope and morphometric study. Materials and Methods: Twenty one adult female albino rats were used and randomly divided into three equal groups: Control group; Aspirin group was given 100 mg/kg body weight of aspirin; the third group was given extract of S. persica at 500mg/kg dissolved in normal saline and aspirin. Animals treated daily for 2 weeks then sacrificed by cervical dislocation. Stomach tissues were excised for light and scanning electron microscopic study and morphometric study. Results: Oral administration of aspirin induced marked changes in gastric mucosa detected by both light and scanning electron microscope with severe erosions, exfoliation and ulcer formation. The addition of S. persica significantly decrease gastric damage and could protect gastric mucosa against the injurious effect of aspirin. Conclusions: These results concluded that aspirin combined with S. persica in comparison with aspirin induced less gastric mucosal damage and this protective effect might be due to the anti-inflammatory and antiulcer activity of S. persica