The utility of antioxidant enzymes, via superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX) and glutathione peroxidase (GPX), as biomarkers of lead pollution in urban atmosphere of Baku was investigated by using the Pyrchantha coccnia. At higher lead concentrations (105.74 ppm), CAT, SOD, APX and GPX exhibited remarkable induction (22.9968, 3.3664, 3.324 and 81.318 unit g-1 FW, respectively) with increasing in the concentration of lead in comparison to the control (11.1008, 2.3184, 2.39, and 21.492 unit g-1 FW, respectively). Based on the above study, it is evident that Pyrchantha coccnia can be used as a bioindicator to monitor the effect of heavy metals on the antioxidant content.