Objective: This study was conducted for correlating the early radiological findings of different surgical causes of vomiting in the neonates with surgical findings. Patients and methods: From January 2009 to September 2012, 101 neonates presented with surgical cause of neonatal vomiting were referred to Diagnostic Radiology Department at Sohag University Hospitals and private sectors. Abdominal X-ray, abdominal ultrasound and Doppler and contrast imaging were done to identify the surgical causes of vomiting with clinical and surgical correlation. All cases were managed surgically by one pediatric surgeon in Pediatric Surgery Unit at Sohag University Hospitals. Patients with vomiting caused by non-surgical causes were excluded. Results: Our study compromised 101 vomiting neonates (72 boys and 29 girls) with male sex predominance. Male to female ratio was 2.5:1. Sixty four patients were found to have congenital hypertrophic pyloric stenosis (CHPS), 19 cases with jejuno-ileal atresia (JIA), 8 cases with duodenal atresia (DA), 2 cases with pyloric atresia, 2 cases with volvulus, 2 cases with complicated congenital inguinal hernias, 2 cases with congenital bands, 1 case with malrotation, and 1 case internal hernia. Radiological examinations were diagnostic in most of the cases and allied with surgical findings. Conclusion: Persistent vomiting in the neonatal period may be indicative of serious surgical conditions and requires neonatal and pediatric surgical involvement. Differentiating between all theses causes is difficult, it relies on good history taking and examination and early appropriate radiological workup.