Introduction: A cervical disc prolapse (CDP) is a protrusion of one of the discs in the neck compressing a nerve root or the spinal cord. Anterior cervical discectomy and cage fusion (ACDF) is one of main surgical modalities to decompress the neural tissue and to stabilize the cervical spine.

Objective: This is a retrospective observational study of clinical and radiological outcomes of ACDF, in patients with CDP with Signs & Symptoms of myelopathy and/or radiculopathy.                                                                                                                         

Methods: Forty patients diagnosed with single, double and triple level degenerative cervical disc prolapse, presented to neurosurgery department, Qena university hospital, South Valley University from January 2013 to August 2015 were enrolled in the study. Complete clinical and radiological evaluation of the patients was done. ACDF was done after failure of conservative medical treatment. All patients were operated upon doing anterior cervical discectomy and fusion (ACDF) using Polyetheretherketone (PEEK) cage and artificial bone substitute. Preoperative & Postoperative Clinical assessment was done using multiple scores including Modified Japanese Orthopaedic Association (MJOA) score. Neck disability index (NDI), and Visual analogue score of neck pain (VASNP). Patients were followed up at 3, 6 and 12 months postoperatively. Radiographic assessment for disc height and C2-7 Cobb angle 3 months postoperative was also done. The complications noted were documented. The statistical analysis was done using SPSS software (version 16.0).   Results: Out of the 40 patients, 2 patients had postoperative motor power deterioration. The remaining 38 patients were followed up. All of them had a reported improvement of symptoms and signs according to MJOA, VASNP and NDI scores. An immediate postoperative dysphagia was reported in 13 patients but, it resolved within few days.                                                                             

Conclusion: ACDF is an effective and a safe surgical procedure for herniated cervical disc causing neurological insult in order to avoid permanent or irreversible neurological deterioration