The old flood plain of the River Nile, Egypt, situated between the recent flood plain of the River Nile and the limestone plateau, has been challenged from different types of geo-environmental hazards. This zone is under the focus of the government, organizations, and private sectors for different activities and investments. Many projects have been assigned and constructed in this zone including urban, infrastructure, and industrial projects. Most of the geo-environmental hazards that impact the development activities in this zone are related to natural and man-made factors. The current study  deals with the investigation of the potential geo-environmental hazards in the new projects west of El-Kawamel village, Sohag, Egypt. The study is based upon the interpretation of high resolution satellite images, geological maps, and physiographical characteristics with the help of field and laboratory analysis. The results and outcomes indicate that the potentially expected natural and man-made geo-environmental hazards in the low desert zone are: 1) karstification and sinkholes; 2- sand accumulations; 3- ٌrock falls; 4- flash floods; 5- problems associated with Pliocene clay; 6- wastewater disposal site; and 7- old abandoned quarries. A detailed geo-environmental hazard map has been created. Suitable remediation methods have been assigned to minimize the impact of these problems.