In mountainous environment such as the area between Sohag and Hurghada, a vital highway has been proposed. Mapping and evaluating the complex geographical, geomorphological, geological, and environmental impact processes, using remote sensing and GIS techniques have been implemented in this study, to predict the more favorable path for the proposed highway. Different types of thematic, environmental, and economic data records, extracted from satellite images, aerial photo mosaics, topographic and geologic maps and field investigations were analyzed and integrated. Paths 1, 4, and 5 for sections 1, 2, and 3 respectively have the lowest possible degree for flash floods, curvature degree, rock obstacles, as well as economical problems. Some additional engineering measures can be proposed, to mitigate any other probable hazards along the selected path.