Paracetamol (acetaminophen) (PA) is a widely used as
an analgesic and antipyretic drug that is commonly available in
without a prescription. Paracetamol has been used to treat many
diseases such as headache, muscle aches, arthritis, backache,
toothaches, colds, and fevers. It cures pain in mild arthritis but has no
effect on the underlying inflammation and swelling of the joints. It has
been reported as the common cause of drug toxic ingestion. These
studies aim to compare the effect of some Paracetamol derivatives
such Phenacetin, p-nitroacetanilide, p-bromoacetanilide and nacetylanthranilic
acid on liver structure to avoid Paracetamol cancer
effect during its metabolism. From the histological point of view, it
has been found that p-nitroacetanilide is the best alternative due to its
metabolite products.