Abstract: Patients' satisfaction with health care service is mainly dependent on the duration and efficiency of care, degree of communication and empathetic with the health care providers. Patient’s opinion about hospital services is one of the main factors contributing to the success of the hospital. Aim of the study: This study was conducted to determine inpatients satisfaction with health services in Sohag University Hospital. Subject and Method: A cross sectional study was carried out for a period of 8 months (from March to December, 2017) in the four major departments in Sohag University Hospital and it included 1819 inpatients. Interview questionnaire was used for collecting data about inpatients' general characteristics and evaluating inpatients satisfaction with the services. Results This study revealed that the overall satisfaction was low (156.74). As regard subscales of satisfaction, the highest satisfaction was with the time spent with doctors (6.05) followed by general satisfaction with services (22.35), technical quality of doctors (35.64) then communication with doctors (14.67). While the lowest mean satisfaction score was reported as regard the financial aspects (24.27). Conclusion: Improving the health services dimensions especially the financial aspects improve the level of overall satisfaction with hospital services. Key words: General satisfaction, Technical Quality, Communication, Financial aspects