Abstract
Background
Patients with liver cirrhosis are generally considered "auto-anticoagulated" because of coagulopathy and thrombocytopenia. However, deep venous thrombosis (DVT) has been reported in patients with liver cirrhosis.
Aim Of the work
The aim of this study is to evaluate the role of protein C, protein S, and antithrombin
Ill deficiency as risk factors for portal vein thrombosis (PVT) in cirrhotic patients.
Methods
The levels of protein C, protein S, and antithrombin Ill in 14 cirrhotic patients with
PVT, 25 cirrhotic patients without PVT, and 25 healthy controls were determined and
statistically analyzed.
Results and conclusions
There is statistically non significant difference between the levels of protein C,
protein S, and antithrombin Ill in the cirrhotic patients with and without PVT
suggesting that PVT occurs mainly due to other causes as local stasis in the portal
vein. However, Levels Of protein C, protein S, and antithrombin Ill were Significantly
lower in the cirrhotic patients when compared to the healthy controls mostly due to
decreased hepatic synthesis Of these factors.
Role of protein C, protein S, and antithrombin Ill deficiency in
coagulopathy in cirrhotic patients with portal vein thrombosis