Context: Liver is an interesting organ with high regenerative capacity.
Objective: giving insight about the cellular, molecular, and genetic mechanisms of liver regeneration, after partial hepatectomy. Studying its clinical applications: 1-Living donor liver transplantation, which is the ethical form of liver transplantation. 2- Cell therapy as an alternative tool for organ donation. The ethics of these application.
Data resources: evidence based speculations about the mechanisms controlling liver regeneration in a model of 70% partial hepatectomy at the cellular, molecular and genetic levels. Living donor liver transplantation, we review its application in the world and in Egypt and its outcome. Based on reports about hepatocyte transplantation, and stem cell therapy, we discuss how promising to apply in treating liver diseases.
Conclusion: Regeneration allows the liver to recover lost mass without impairing viability of the entire organism. Liver regeneration represents an integral part of many therapeutic tools of liver diseases, including: Living donor liver transplantation, and the great promising application, hepatocyte transplantation, and stem cell therapy. Thus, the need to understand liver regeneration is currently becoming more important in treating liver diseases.
Key words; Liver, Hepatectomy, Regeneration