Edwardsiellosis (Emphysematous putrefactive disease) is one of the most serious bacterial diseases affecting Clarias gariepinus (C. gariepinus) fish. This study reported the most characteristic lesions including skin depigmented areas, external hemorrhages, small cutaneous ulcers, gas filled pockets give rise offensive odour and ascitis. The disease prevalence was 5.2% in the examined fish sample and 16.7% in the clinically diseased fish. The isolated strains were identified by the conventional biochemical tests and API20-E as E. tarda. The isolated strain was pathogenic and its LD50 was 1.5x105CFUml-1 . Combination of carvacrol and its precursor cymene (100ppm of each) for 14 days as food additives controlled the disease in C. gariepinus while 50ppm of them reduced mortality to10% and 55mgkg-1 body weight of Oxytetracycline reduced the mortality rate to 20%.