There is increasing evidence that atherosclerosis, the underlying cause of coronary artery disease (CAD), has an inflammatory pathogenesis. Some inflammatory molecules such as cell adhesion molecules (CAMs) are associated with atherosclerosis and thrombosis. In the current study, 40 patientswith newly diagnosed myocardial infarction and another 40 non cardiac healthy volunteers were chosen. Inflamatory molecules such as cellular adhesion molecules; platelets (P)-selectin and intracellular cell adhesion molecules-1 (ICAM-1) were analysed in the serum of both groups by ELISA. Levels of serum p-selectin and ICAM-1 were significant higher in CAD patients (201±12.3 ng/ml and 322.8±17.8 ng/ml respectively) than those in non cardiac group (130.5±31.8 ng/ml and 241.2±77.4 g/ml respectively). These results were apparent in hypertensive, male, age (<40 years), smoker, hyperlipidemic and high BMI than others. Cellular adhesion molecules not only associated with CAD but also, had a role in pathogenesis of CAD.