Psychogenic non-epileptic seizures (PNES) account for 10–40% of patients referred to epilepsy centers. Distinguishing
between NES and epileptic seizures is a very difficult task that faces the clinician. This study included 20 epileptic
patients and 20 patients suffering from psychogenic non-epileptic seizures. All patients were subjected to a detailed
medical and neurological history and examination, psychometric tests including intelligence assessment, Minnesota
Multiphasic Personality Inventory and the following investigations: Routine laboratory investigations, Pre and post-ictal
Creatinephosphokinase, Routine EEG, Prolonged video EEG recordings with the use of induction technique, Auditory
event related potentials (P300) using oddball paradigm done in three sessions, preictal, postictal (within 6 hours from
the onset of fits), and interictal (6-48 hours from the onset of fit) and CT brain for epileptic group. The comparative
studies included: demographic and neurological history variables, seizure semiology, psychological testing, serum CPK
and event related potentials measurements. The combination of more than one of these variables particularly P300 and
MMPI-II raised the diagnostic accuracy of PNES even without video EEG.
(Egypt J. Neurol. Psychiat. Neurosurg.,