DISEASES OF THE CENTRAL NERVOUS SYSTEM
Medical diseases
Meningitis
Definition
Pachymeningitis
Leptomeningitis
Types of meningitis
SEPTIC MENINGITIS
Causes
Pathology of Meningococcal Meningitis
Gross Picture
Microscopic Picture
C.S.F. Changes
Clinical Picture
Local effects and complications
General effects and complications
Viral (aseptic meningitis)
C.S.F. Changes
Tuberculous Meningitis
Pathological features
CSF changes
Complications
Brain Abscess
Etiology: Causative organisms, Routes of infections
Sites, Pathological Features, Clinical picture and Complications
Encephalitis
Definition
Viral encephalitis
Demyelinating diseases
Definition
MYELIN
Functions
Etiology of Demyelinating diseases
Classification of Demyelinating diseases
Demyelinating myelinoclastic diseases
Demyelinating leukodystrophic diseases
Demyelinating diseases affecting the central nervous system
Demyelinating diseases affecting the peripheral nervous system
Signs and symptoms
Multiple sclerosis (MS)
Definition
Etiology of MS
Pathogenesis of MS
Gross and Microscopic pictures and Clinical features
Degenerative diseases of CNS
Definition
Etiology and pathogenesis/ mechanisms
Genetics
Protein misfolding
Programmed cell death (PCD)
Transglutaminase
Alzheimer’s disease
Definition
Etiology
Genetic hypothesis
Familial forms of autosomal dominant
Inheritance of the ε4 allele of the apolipoprotein E (APOE)
Mutations in TREM2 gene
Cholinergic hypothesis
Amyloid hypothesis
Tau hypothesis
Other hypotheses
Other hypotheses
Retrogenesis is a medical hypothesis
Other risk factors
Pathogenesis
PATHOLOGICAL FEATURES: Gross and microscopic
CLINICAL PICTURE AND PROGNOSIS
Pick's disease
Definition
Clinical features
Etiology
PATHOLOGICAL FEATURES
Differences from Alzheimer’s disease
Parkinsonism
Definition
Parkinsonian syndrome
Pathogenesis of Parkinsonism
Lewy body
Gross and microscopic pictures
Clinical features
Dementia
Definition
Diagnosis of dementia
Memory
Differential diagnosis
Delirium
Depression
Pseudodementia
Classification of dementias based on the cause
Classification of dementias based on the site
