Presentation for postgraduate student in Obstetrics and Gynecology.
- Kisspeptins play essential roles in reproduction.
- They are involved in in utero sexual development and determine the onset of puberty.
- After sexual maturation, kisspeptins regulate HPG axis function by modulating gonadotrophin release.
- Potential clinical uses of kisspeptins include the treatment of :
- delayed or precocious puberty,
- subfertility,
- down regulation of sex steroids in the treatment of sex steroid-dependent tumors,
- contraception –leiomyoma-endometriosis
- treatment of metastatic cancers.