Immuno-Pathology
Diseases or disorders of the immune system
Categories of immune disorders
Hypersensitivity reactions
Type I hypersensitivity (anaphylaxis); Immediate type
Phases of type I hypersensitivity
Clinical examples of type I HSR
Localized → atopic diseases
Systemic → anaphylaxis shock
Type II hypersensitivity (antibody dependent cytotoxicity)
Mechanisms involved in this reaction (antibody dependent cytotoxicity)
Type III hypersensitivity (immune complex disease)
Localized type III reaction or Arthus reaction
Systemic or circulating immune complex diseases
The pathogenesis of immune complex disease
Factors affecting immune complex disease
Type IV hypersensitivity (delayed hypersensitivity-cell mediated immunity)
Forms of type IV HSR
Delayed type hypersensitivity
T-cell mediated cytotoxisity
Contact dermatitis
Transplantation rejection
Tissue transplantation
Classifications of graft rejection reactions according to the course
Hyperacute rejection
Acute rejection
Chronic rejection
Graft versus host disease
Autoimmunity
Self-tolerance, definition and mechanisms
Clonal deletion
Clonal anergy
Peripheral suppression of T cells
Mechanisms of autoimmune diseases
Genetic factors in autoimmunity
Microbial Ags in autoimmunity
Mitogens
Classification of AI diseases
Single organ specific AI diseases
Systemic AI diseases
Immunodeficiency
Immunodeficiency diseases (IDD)
Primary (inherited) diseases
Secondary acquired diseases
Amyloidosis
Classification of amyloidosis
Systemic - kidneys, liver, spleen, adrenals, lymph nodes
Localized - various organs
Tumor Immunology
Cancer immune surveillance
