ØOsteoporosis (OP) constitutes a major worldwide public health burden characterized by enhanced skeletal fragility. Bone metabolism is the combination of bone resorption by osteoclasts and bone formation by osteoblasts. Whereas increase in bone resorption is considered as the main contributor of bone loss that may lead to osteoporosis.
ØWith aging, the composition of bone marrow shifts to favor adipocyte formation, increase in osteoclast activity, and decrease in osteoblast functions.