Topic

 

Objectives

 

Learning strategy

 

  Devices & Methods

Course Matrix of Gene Toxicity in Forensic Medicine &Clinical Toxicology

  Structure activity  relationship

 

Gain the basic knowledge of:

Relation between chemical structure and type of effect

Relationship between physiochemical and intensity of effect

Quantitative structure activity relationships

Lectures

Assignment

Computer for electronic  lectures

 

 Types of mutations: gene mutations, structural chromosomal aberrations, genome mutations

 

Gain the basic knowledge of

Types of mutations

Gene mutations

Chromosomal aberrations

Genome mutations

Lectures

Assignment

Computer for electronic  lectures

 

 Conversion of mutations to altered proteins

 

Gain the basic knowledge of

Conversion of mutations to altered proteins

Lectures

Assignment

Computer for electronic  lectures

 

DNA repair

 

Gain the basic knowledge of

DNA repair

 

Lectures

Assignment

Computer for electronic  lectures

Mutagenicity tests

 

Gain the basic knowledge of

Mutagenicity tests

 

Lectures

Assignment

Computer for electronic  lectures

  The threshold level for mutagenicity

 

Gain the basic knowledge of 

The threshold level for mutagenicity

 

 

Lectures

Assignment

Computer for electronic  lectures

 Carcinogenicity

 

Gain the basic knowledge of

Definitions

Mechanisms of action

Sources of carcinogens

Identification and classification of carcinogens

Lectures

Assignment

Computer for electronic  lectures

 

 Teratogenicity

 

Gain the basic knowledge of

Mechanisms of action

Genotoxicity

Maternal and placental toxicity

Teratogenic agents

Lectures

Assignment

Computer for electronic  lectures