Abstract Background Get rights and content Osteopontin (OPN) is an extracellular matrix protein of the integrin family that is involved in several biological pathways. Genetic polymorphisms in OPN gene has been found associated with many types of cancer. Aims In this investigation, we aimed to study the possible role of OPN and its rs11730582 C/T single nucleotide polymorphism (SNP) in ... إقراء المزيد

Abstract Background.Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes onco-genic features including cell proliferation, survival,migration, and angiogenesis. Here, we analyzed the correlation between the expression pattern of (osteopontin and CA15.3) and clinic-pathological status ofbreast cancer and other standard prognostic factors. Patients and methods.A case control study with 60 female breast cancer patients and 20 ... إقراء المزيد

Abstract Osteopontin (OPN) is an extracellularmatrix protein that is overexpressed in various cancers and promotes oncogenic features including cell proliferation, survival,migration, and angiogenesis, among others. OPN can participatein the regulation of the tumormicroenvironment, affecting both cancer and neighboring cells. Here,we review The role of single-nucleotide polymorphism (SNP)-443 of the OPN gene in cancer aggressiveness. إقراء المزيد

ABSTRACT Apoptosis and aging are complementary and cooperative processes that reduce cell proliferation and promote resistance to tumor development. Cellular levels of oxidative stress increase during physiological aging and tend to induce apoptosis, thereby influencing cellular and tissue aging and life span. Aim of study: is to determine the relationship between aging and apoptotic indices in the form of s-Fas ... إقراء المزيد

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Seminar إقراء المزيد

Seminar إقراء المزيد

Seminar إقراء المزيد

Seminar إقراء المزيد