The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, (1)H NMR and (13)C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, UV-vis and ... Read more

1442One-PotMulticomponentSynthesisofNovel2-Tosyloxyphenylpyrans underGreenandConventionalConditionwithAnti-inflammatoryActivity Vol54 AhmedKhodairy, a AliM.Ali, a * MoustafaO.Aboelez, b andM.T.El-Wassimy a a DepartmentofOrganicChemistry,FacultyofScience,SohagUniversity,Sohag82524,Egypt b DepartmentofPharmaceuticalMedicinalChemistry,FacultyofPharmacy,SohagUniversity,Egypt *E-mail:elssan@yahoo.com AdditionalSupportingInformationmaybefoundintheonlineversionofthisarticle. ReceivedApril16,2016 DOI10.1002/jhet.2730 Publishedonline19July2016inWileyOnlineLibrary(wileyonlinelibrary.com). Amild,efficient,andenvironmentallygreenprotocolforthesynthesisof2-tosyloxyphenylpyran derivatives3-11viareactionof2-tosyloxybenzaldehyde(1)withmalononitrileandsomeketonicreagents inone-pot,threecomponentreactionwithinfewminutesunderstirringinmethanolinpresenceofammonium hydroxidesolutionorultrasonicirradiation.Ontheotherhand,thesameproducts3-11wereobtainedby traditionalmethod,ontreatmentof2-tosyloxybenzilidinemalononitrile(2)withthesameketonicreagents inrefluxingethanolinpresenceofTEA.2-Tosyloxyphenylpyranopyrazoles12and13wereobtainedvia treatmentofcompound1withmalononitrile,hydrazinehydrateorphenylhydrazineandethylacetoacetate, inone-pot,multicomponentreaction(MCRs).Thestructuresofthenewcompoundswereelucidatedbyele- mentalandspectralanalyses.Thenewlysynthesizedcompoundsshowedpromisinganti-inflammatoryactivity Read more

Reaction of 4,6-diamino-3-cyano-2-methylthiopyridine (I) with chloroacetyl chloride or acetic acid afforded the corresponding 6-acetamide derivatives IIa and IIb, respectively. Chloroacetamide derivative IIa reacted with various thiols, secondary amines, potassium thiocyanate, compounds containing active methylene group, 1-anilino-2,2-dicyanoethenethiolate, and o-mercatocyanopyridines to give S-alkyl, N-alkyl, thiazole, pyrrole, thiophene, and thienopyridine derivatives, respectively. Antibacterial and anti-inflammatory activities of some new pyridine derivatives were studied ... Read more

: Synthesis of novel N-acyl hydrazones of nicotinic acid hydrazide via condensation of nicotinic acid hydrazide 3 with the corresponding aldehydes 1, 2 are described. Their hypolipidemic activities were evaluated in high cholesterol diet fed rat model. The hydrazones were found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree ... Read more