Ahmed Abudeif Abdelaal

مدرس - مدرس وإستشاري أمراض الكبد والجهاز الهضمي والحميات ومناظير الجهاز الهضمي

كلية الطب

العنوان: قسم طب المناطق الحارة والجهاز الهضمي - مستشفى سوهاج الجامعي - الدور الثالث - المبنى المجاني


2023 | الكلمات المفتاحية cirrhosis, spontaneous bacteri,
Serum copeptin is associated with major complications of liver cirrhosis and spontaneous bacterial peritonitis
Abstract Aim of the study: We aimed to investigate the possible association between serum copeptin and complications of liver cirrhosis, including its potential role as a stress biomarker in spontaneous bacterial peritonitis (SBP). Material and methods: This cross-sectional study included 89 cirrhotic ascitic patients (37 with SBP and 52 without SBP) admitted to Sohag University Hospitals, Egypt, between June 2021 ... إقراء المزيد

2023 | الكلمات المفتاحية Spontaneous bacterial peritoni,
Validation of the diagnostic accuracy  of neutrophil to lymphocyte ratio (NLR)  and mean platelet volume (MPV) in cirrhotic  patients with spontaneous bacterial peritonitis
Abstract Background Spontaneous bacterial peritonitis (SBP) is a signifcant complication among cirrhotic patients with ascites and is associated with high mortality. Early diagnosis and treatment of SBP are crucial, as they are associated with better outcomes and lower mortality. The neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) are routine, inexpensive, easily measured markers readily obtained from a complete blood ... إقراء المزيد

2022 | الكلمات المفتاحية acute-on-chronic liver failure,
Characteristics and predictors of short-term mortality in decompensated cirrhotic patients with acute-on-chronic liver failure
Abstract Aim of the study: We aimed to investigate the characteristics of acute-on-chronic liver failure (ACLF) and factors associated with 28-day mortality in patients with ACLF. Material and methods: This prospective study included ACLF patients based on the European Association for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) Consortium criteria, admitted between March 2021 and February 2022. We examined ... إقراء المزيد

2021 | الكلمات المفتاحية Gene polym, vitamin D receptor,
Vitamin D receptor gene polymorphisms and risk of hepatocellular carcinoma in hepatitis C-related liver cirrhosis
Abstract Background: HCV is a major risk factor for HCC; however, the exact mechanism of hepatocarcinogenesis is still not fully understood. Host genetic factors have been reported to play a significant role. Experimental studies support the tumor inhibitory effect of vitamin D on HCC cells. Several single nucleotide polymorphisms (SNPs) have been depicted in the vitamin D receptor (VDR) gene. ... إقراء المزيد

2020 | الكلمات المفتاحية Immune checkpoint inhibitors,
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma A New Era in Treatment of Advanced Disease
ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary hepatic cancer with high fatality and recurrence rates. The prognosis of advanced HCC is dismal, and treatment was limited for a decade to sorafenib with limited effectiveness and miserable overall survival. The advent of immune checkpoint inhibitors (ICPIs) provides a considerable step in the treatment of several advanced malignancies including HCC ... إقراء المزيد

2020 | الكلمات المفتاحية Tp53,
Study the Role of Tp53 in the Development of Hepatocellular Carcinoma in HCV Infected Patients
Background: Hepatocellular carcinoma (HCC) is considered as the primary malignancy of the liver that usually occurs on top of chronic viral hepatitis. The TP53 (tumor protein 53) is a tumor suppressor gene which is the key in tumor development and progression and the single nucleotide polymorphism (SNP) of the p53 gene codon 72 (p53Arg/Pro) changes the structure of the protein. ... إقراء المزيد

2020 | الكلمات المفتاحية HCC, CCR2 (V6, MCP-1 -2518 A/G,
Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt
Background: HCC is the most common primary tumor of the liver .It is the fifth common cancer in men and the eighth common in women and is the second leading cause of cancer-related death in the world. The MCP-1 is a chemokine and a potent chemotactic factor for monocytes. MCP-1 expression in tumor cells is significantly linked to the extent ... إقراء المزيد

2019 | الكلمات المفتاحية VITAMIN D, HCC, HCV, Liver disease,
Vitamin D and Hepatitis C Virus-related Liver Disease
ABSTRACT Vitamin D through the vitamin D receptor (VDR) is involved in the control of bone and calcium homeostasis, immunoregulation, cellular differentiation, and anti-inflammatory actions. The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D with chronic liver disease, chronic hepatitis C (CHC) infection, and hepatocellular carcinoma (HCC) remains to be evaluated. The purpose ... إقراء المزيد

2019 | الكلمات المفتاحية VDR, SNP, HCC,
VDR Gene Polymorphisms and Risk of Hepatocellular Carcinoma
ABSTRACT Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the fourth most common cause of cancer death. The development of HCC is a complex and multi-factorial process, in which both environmental and genetic features interfere and contribute to malignant transformation. Numerous genetic studies have reported associations between single nucleotide polymorphisms (SNPs) and the presence of ... إقراء المزيد

2019 | الكلمات المفتاحية HCC, Epidemiology, HCV, Egypt, Globocan 2018,
Epidemiology and Risk Factors of Hepatocellular Carcinoma in Egypt
Hepatocellular carcinoma (HCC) is the most prevalent primary cancer of the liver accounting for 75% to 85% of primary liver cancers worldwide. It is the sixth most prevalent cancer in the globe and the fourth most prevalent cause of death from cancer, it occurs in males 2 to 3 times higher than in females. Geographical distribution of HCC varies throughout ... إقراء المزيد