Several classes of antihistamine drugs are widely distributed over the world's medication although their intensive side effects are in the high dosages. In the present manuscript, we report a simple, cost-effective and sensitive voltammetric determination of the meclizine antihistamine drug using unmodified/bare graphite screen-printed electrodes (GSPE) within physiological micellar medium of sodium dodecyl sulphate (SDS). The GSPE show an electrochemical ... Read more

Nifedipine and atenolol dugs are conjugated in several anti-hypertensive pharmaceutical formulations. Herein, a reproducible and sensitive voltammetric procedure has been developed for the simultaneous analysis of nifedipine and atenolol for the first time using MgO − nanoplatelets modified screen-printed electrodes (MgO − SPEs) _via_ differential pulse voltammetry (DPV). Two very well-resolved and reproducible signals/oxidation peaks with a voltammetric separation of ... Read more

The screen-printed technique is widely used as an efficient tool for electrochemical analysis in environment, clinical and agri-food areas. Significantly, it has the ability to transfer electrochemical laboratory experiments into the field. In the present work, we report a highly sensitive, simple, low-cost protocol for determination of amlodipine (AML) using bare/unmodified and DNA-modified screen-printed electrodes (SPEs). The immobilization of DNA ... Read more

Two simple, selective, precise and highly sensitive high‐performance thin‐layer chromatography (HPTLC) methods have been developed and validated for analysis of five angiotensin II receptor antagonists, namely losartan, irbesartan valsartan, candesartan and olmesartan, which are widely used in clinical practice. HPTLC of the drugs was performed on pre‐coated silica gel HPTLC plates 60 F254 by development using a mobile phase composed ... Read more

A selective, accurate, precise, and highly sensitive HPTLC assay with reflectance/fluorescence densitometry was developed to separate and quantify some angiotensin II receptor blockers (ARBs), namely, losartan potassium, irbesartan, valsartan, and olmesartan medoxomil, in tablets and plasma. Separation of the target ARBs was performed on precoated silica gel HPTLC plates developed using chloroform–glacial acetic acid (7.5 + 2.5, v/v) mobile phase. ... Read more

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A high-performance thin-layer chromatographic (HPTLC) method was performed for simultaneous quantification of four angiotensin II receptor antagonists, namely, losartan, irbesartan, valsartan, and olmesartan. The method based on HPTLC separation of the four drugs using reflectance–absorbance mode at 255 nm. Separation was carried out on pre-coated silica gel HPTLC plates, using chloroform– glacial acetic acid (7.5:2.5, v/v) as mobile phase. The ... Read more