Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt


Vascular endothelial growth factor and hepatic neoangiogenesis in hepatitis C associated chronic liver disease
Worldwide Egypt had the highest prevalence of hepatitis C virus infection. Angiogenesis is a complex process that regulated by many factors, including vascular endothelial growth factor (VEGF). In the liver hepatic satellite cells (HSCs), Kupffer cells, regenerating hepatocytes and existing endothelial cells are responsible for the process of neoangiogenesis and production of vascular endothelial growth factor (VEGF). AIM OF THE ... Read more

2017 | Keywords CD34, Chronic Hepatitis C,
CD34 Expression as a marker of progression of chronic hepatitis C
In Egypt, the rate of death/transplantation, decompensation and HCC in patients with compensated HCV cirrhosis is 4.58%, 6.37% and 3.36%, respectively. It is estimated that Egyptian patients with HCV cirrhosis had an annual incidence of HCC with 5.3%. CD34 is a 110-kDa transmembrane glycoprotein present on leukemic cells, endothelial cells and stem cells). CD34 is preferentially expressed on the surface ... Read more

2017 | Keywords liver cirrhosi, serum selenium,
Serum Selenium Level in Patients with Chronic Liver Disease
BACKGROUND: Selenium has been shown to protect against liver necrosis. Selenium deficiency has been involved in the pathogenesis of chronic hepatitis B and C related hepatocellular damage. Serum selenium concentration in cirrhotics was found to be low, supportive selenium administration may be beneficial for them. Reduced selenium levels result in accumulation of lipid peroxides which accelerate the growth of hepatocellular ... Read more

Prevalence of Functional Gastrointestinal Disorders Among Patients with Rheumatoid Arthritis
INTRODUCTION AND OBJECTIVE:Rheumatoid arthritis (RA) is a common autoimmune inflammatory disorder characterized by persistent joint affection mainly and extra-articular organ involvement as skin, heart and gastrointestinal (GI) systems. Functional GI manifestations are one of the most common extra-articular manifestations of RA as gastrointestinal reflux disease (GERD) and irritable bowel syndrome (IBS). Our study aimed to study the prevalence of GERD ... Read more

2016 | Keywords H. pylori , chronic gastritis,
Immunohistochemical Detection of P53 in Helicobacter Pylori Gastritis
Aim of the work: This study was designed to detect mutation in P53 in cases of non-neoplastic Helicobacter Pylori (H. Pylori) gastritis. Method: 55 cases of chronic H. Pylori gastritis were selected and we used immunohistochemical technique to detect P53 expression and compared it with the five parameters in Sydney system (gastric atrophy, intestinal metaplasia, chronicity, and activity and H. ... Read more

Role of Serum Zinc Level and P300 Event Related Potential in Detection of Minimal Hepatic Encephalopathy
Background: Minimal hepatic encephalopathy (MHE) is defined as hepatic encephalopathy (HE) without symptoms on clinical/neurological examination, but with deficits in some cognitive areas that can only be measured by neuropsychometric testing. Aim: Our aim was to study serum zinc levels in cirrhotic patients with and without MHE and correlate it with the results of neuropsychological tests and P300 event related ... Read more

Metabolic Factors Associated with Heapatic Steatosis and Fibrosis in Patients with Chronic Hepatitis C
OBJECTIVE: Hepatic steatosis is a common histological feature in chronic hepatitis C (CHC), but its pathogenic mechanisms are not completely understood. We aimed to evaluate the metabolic factors associated with hepatic steatosis and fibrosis in CHC patients, and the relation between metabolic syndrome (MS) and CHC. PATIENTS AND METHODS: This study included 71 patients with chronic HCV infection who underwent ... Read more

The Role of Hepatic Progenitor Cells (HPCs) and the Predictors of Sustained Virological Response (SVR) to Interferon Therapy in Chronic Hepatitis C Infected Patients
Background: Studying the predictors of SVR to pegylated interferon (PEG-INF) alfa-2a and ribavirin (RBV) therapy in chronic hepatitis C-infected patients is crucial for selecting those who would benefit from therapy. Increasing HPCs in hepatitis C-infected patients were shown to be correlated with increased fibrosis and response to therapy. HPCs could be detected in the liver by immunohistochemical expressions of cytokeratin ... Read more

Urocortin and cytokines in gastric mucosa: Relationship to inflammatory activity before and after medical eradication of Helicobacter pylori.
BACKGROUND AND AIMS: There is a debate whether the majority of gastritis mucosal injury occurs as a direct result of _H. pylori_ infection or as a result of immune cell damage from abundant mediators of inflammatory response. Recently, Urocortin (Ucn) has emerged as a mediator of the gastrointestinal (GI) responses to noxious stimuli. Interleukins 1β (IL-1β) and interleukin-10 (IL-10) may ... Read more

Prognostic Value of Oral Glucose Tolerance Test, Insulin Like Growth Factor-I and Transferrin in Cirrhotic Patients
BACKGROUND: Glucose intolerance occurs frequently in patients with liver cirrhosis. However, few studies have assessed its prognostic value in patients with liver cirrhosis. AIM: To evaluate the importance of oral glucose tolerance test (OGTT), insulin-like growth factor-I (IGF-I) and serum transferrin (TRF) in prediction of disease outcome in patients with posthepatitic liver cirrhosis . METHODS: Seventy-four patients with posthepatitic liver ... Read more