bjectives: The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of IL‐17 and 25 hydroxycholecalciferol (25(OH)D3) in the disease pathogenesis and progression. Materials and Methods: Across‐sectional study has been conducted on 135 patients with active acne vulgaris of various severities and 150 matched controls. ELISA assays of serum and tissue ... إقراء المزيد

Leprosy or Hansen’s disease (HD) is a chronic infectious disease caused by Mycobacterium leprae. The ratio of malondialdehyde (MDA)/superoxide dismutase (SOD) may be considered as an index of oxidative stress (OS). Objective To assess the OS by estimating the levels of antioxidant enzyme (SOD), lipid peroxidation products (MDA) and the ratio of MDA/SOD in the skin of paucibacillary (PB) and ... إقراء المزيد

Colorectal cancer (CRC) is a common cause of death worldwide, and represents the third most common form of cancer and the second leading cause of cancer-related death in the world. Human paraoxanase (PON1) is a Ca-dependent esterase synthesized in liver and related to high density lipoprotein (HDL) and protecting low density lipoprotein (LDL) by hydrolysis of lipid peroxides. This study ... إقراء المزيد

Background Diabetes mellitus type 2 (T2DM) is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. Vaspin (visceral adipose tissue-derived serpin) is a member of the broadly distributed serpin (a protein superfamily of serine protease inhibitors of ∼500 genes) and is identical to serpin A12. The upregulation of vaspin ... إقراء المزيد

Background: Minimal hepatic encephalopathy (MHE) is defined as hepatic encephalopathy (HE) WITHOUT SYMPTOMS ON CLINICAL/NEUROLOGICAL EXAMINATION, BUT WITH DEFICITS IN SOME COGNITIVE AREASTHAT CAN ONLY BE MEASURED BY NEUROPSYCHOMETRIC TESTING. AIM: OUR AIM WAS TO STUDY SERUM ZINCLEVELS IN CIRRHOTIC PATIENTS WITH AND WITHOUT MHE AND CORRELATE IT WITH THE RESULTS OF NEUROPSYCHOLOGICAL TESTS AND P300 EVENT RELATED POTENTIAL. PATIENTS ... إقراء المزيد

A series of new 4-tosyloxyphenylpyranderivatives 3-11 were efficiently synthesized via one-pot, multicomponent reaction (MCRs) of 4-tosyloxybenzaldehyde 1, malononitrile and some ketonic reagents through green chemistry protocols using Ultrasonic irradiation technique or stirring in water at room temperature. All products were obtained in excellent yield, pure at low cost processing and short time. The structure of all compounds was characterized by ... إقراء المزيد

The hepatitis C virus (HCV) epidemic in Egypt is unique in the world as there are many publications suggest that over 15% of the people in Egypt are infected ,this is ten times greater than in any other country in the world.Aim: To validate a simple ,inexpensive, non invasive markers (Fib-4, APRI,syndecan-1 and apolipoprotein A1(ApoA-1)) for detection of liver fibrosis ... إقراء المزيد

Autoimmune diseases have common properties characterized by abnormal blood chemistry with high serum autoimmune antibodies, and inflammatory mediators. Those causative pathological substances (CPS) cannot be excreted by physiological mechanisms. Current treatments for autoimmune diseases involve steroids, cytotoxic drugs, plasmapheresis and monoclonal antibodies. Wet cupping therapy (WCT) of prophetic medicine is called Al-hijamah that treats numerous diseases having different etiology and ... إقراء المزيد

Colorectal cancer (CRC) is a leading cause of cancer-related death. Oxidative DNA damage may contribute to cancer risk and the antioxidant paraoxonase is one endogenous free radical scavenger in the human body which could therefore exert an influeence. Purpose: Aim of this study was to determine the role of serum arylesterase (ARE) and paraoxonase 1(PON1) activities in CRC patients and ... إقراء المزيد

Recent studies have identified a set of serological markers for telomere dysfunction and DNA damage. In the present study, the levels of 2 serological markers of telomere dysfunction namely chitinase and Nacetylglucosaminidase (NAG) were studied in type2 diabetic mellitus (T2DM) patients. The possibility that genomic damage, accumulation of reactive oxygen species and shorter telomeres may be linked to the onset ... إقراء المزيد