1-Anilinocycloalkanecarbonitriles 1a–c were prepared and reacted with active methylene reagents to give compounds 5a–c through 10a–c and reacted with different other reagents such as benzaldehyde, ethyl aminoacetate, ethyl mercaptoacetate, or hydrazine carbothioamide, which afforded the desired spiro heterocycles compounds 11a–c through 14a–c إقراء المزيد

Thiacalix[4]arenes mono, 1,3di, tri, and tetrasubstituted at the lower rim, including those containing different substituents, were synthesized by the method based on the ability of the phenacyl moiety to serve as the protecting group, as well as to be involved in transalkylation إقراء المزيد

Hydrazinopiperidinomethanethione 2 was prepared and reacted with active halo compounds, carbon disulfide, phenyliso-thiocyanate, ylidenenitriles, and N,S-acetyls to give thiadiazine 4–7 , thiadiazole 8–10 , and pyrazole 11,13 , 14–17 derivatives, respectively إقراء المزيد

New dissymmetric and asymmetric p-tert-butylthiacalix[4]arene derivatives were prepared as a result of the reaction of p-tert-butylthiacalix[4]arene with diethyl bromomalonate in the presence of different alkali metals (Cs, K and Na) in refluxing acetone for 7 days. The structures of the prepared compounds were investigated by IR, 1HNMR and MALDI-TOF mass spectroscopy إقراء المزيد

Starting from thiacalixarene tetraacetates, tetraacetohydrazides have been prepared and then used for the introduction of semicarbazide and thiosemicarbazide fragments into the lower rim by the reaction with phenyl isocyanate and phenyl isothiocyanate in dry toluene. The structures of the prepared compounds were investigated by FT-IR, FAB-MS, 1H NMR, and X-ray crystallography, and their receptor properties were examined by liquid liquid ... إقراء المزيد

Tetra- and tri-thioated derivatives of tetrakis[(ethoxycarbonyl)methoxy]tetrathiacalix[4]arenes were synthesized by thionation with Lawesson’s reagent in dry toluene. The prepared compounds’ structures were investigated by FT-IR, 1H NMR, 2DNMR, MALDI-TOF-MS, and X-ray crystallography إقراء المزيد

Two different 1, 3-Distal thiacalix[4]arenas were prepared by the reaction of thiacalix[4]arenewithphenacyland/orp-nitrophenacylbromideinacetoneoracetonitrile in the presence of dry CsOH. The prepared 1, 3-distal disubstituted thiacalixarenes afforded two pairs of diastereomers upon brominating in chloroform. The obtained diastereomers were separated by fractional crystallization in a mixture dichloromethane-acetone إقراء المزيد

N,N′‐Diphenylpiperidine‐1‐carbohydrazonamide 1 was prepared and treated with halo compounds, active nitriles, diethylhy malonate, ketones, CS2, phenylisocyanate, phenylisothiocyanate, LR, ethyl 2‐cyano‐3,13‐dithiomethylacetate, and benzylidenenitriles to give the corresponding triazines 2–4, pyrazoles 5 and 6, triazoles 7, 8, and 10, triazaphosphole 11, and triazepines 12 – 14, respectively إقراء المزيد

A number of spiro[cyclopentane (cyclohexane, and cycloheptane)-1,4-perhydro[1,3,2]diazaphosphole] derivatives (3a–c, 5a–c, 11a–c, and 12a–c) and spiro-[cyclopentane (cyclohexane, and cycloheptane)-1,4-perhydro[1,3,2]oxaazaphos-phole] derivatives (7a–c) were prepared via an interaction of 2,4-bis-(4-methoxy-phenyl)1,3,2,4-dithiaphosphetane-2,4-disulphide (1) with substances containing two functional groups إقراء المزيد

Template effect of alkali metal ions was employed to prepare three isomers of tetraamide of p-tertbutylthiacalix[4]arene: cone, partial cone and 1,3-alternate. It was demonstrated that pre-organization of four amide fragments attached to the calix[4]arene platform has a strong macrocyclic cooperative effect on the extraction ability of the title hosts إقراء المزيد