mamdouh.fawzi

Mamdouh Fawzy Ahmed Mohamed

Lecturer - Lecturer of Pharmaceutical Chemistry, Head of Pharmaceutical Chemistry Department Lab and Co-ordinate of Clinical Pharmacy Program

Faculty of Pharmacy

Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, 82524 Sohag, Egypt

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Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors

2017 | Keywords Anti-proliferative, Histone deacetylase,
Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors
A group of novel chalcone derivatives comprising hydroxamic acid or 2-aminobenzamide group as zinc binding groups (ZBG) were synthesized. The structure of the prepared compounds was fully characterized by IR, NMR and elemental microanalyses. Most of the tested compounds displayed strong to moderate HDAC inhibitory activity. Some of these compounds showed potent anti-proliferative activity against human HepG2, MCF-7 and HCT-116 ... Read more

Novel chalcone derivatives: Design, synthesis and histone deacetylase inhibition activity

2016 | Keywords HDACIs,
Novel chalcone derivatives: Design, synthesis and histone deacetylase inhibition activity
A series of novel histone deacetylase inhibitors (HDACIs)/chalcone hybrids bearing hydroxamic acid or 2- aminobenzamide group as zinc binding groups (ZBG) were synthesized. The structural formula of the prepared compounds was fully characterized by IR, NMR and elemental microanalyses. Most of the tested compounds showed moderate to strong Histone deacetylase (HDAC) inhibitory activity. In particular, compounds 3b, 3c, 3d and ... Read more