Single and Double strands breaks DNA single-strand breaks (SSBs) arise as a consequence of spontaneous DNAinstability and are also formed as DNA REPAIR intermediates. ... Here we report that ataxia-telangiectasia mutated kinase (ATM) plays a major role in restricting the replication of SSB-containing DNA and thus ... إقراء المزيد

The Antibiotics' spectrum The term broad-SPECTRUM ANTIBIOTIC can refer to anANTIBIOTIC that acts on the two major bacterial groups, gram-positive and gram-negative, or any ANTIBIOTICthat acts against a wide range of disease-causing bacteria. إقراء المزيد

Topoisomerases and Bone marrow toxicity Topoisomerases are ENZYMES that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork. TOPOISOMERASE ... إقراء المزيد

Side effects of Alkylating Agents The most common effect is neutropaenia, which increases the chance of INFECTION. Other side effects include: NAUSEA AND VOMITING: A variety of anti-emetic (anti-NAUSEA) agents are available for patients receiving chemotherapy to help control and even eliminate symptoms of NAUSEA. إقراء المزيد