ABSTRACT: Adenoma-carcinoma sequence was postulated for most colorectal carcinomas. Deregulation of apoptosis & cell proliferation is involved in the pathogenesis of neoplasia. The apoptosis genes characterized in colon cancer are bcl-2, bax & p53. b-catenin plays a role in both cell adhesion & intracellular signaling. Translocation of b-catenin from the cell membrane to the cytoplasm or nucleus is an early ...
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