ABSTRACT AUTHOR INFORMATION Background. Recent data suggest that interferon (IFN)-y is not an essential mediator of acute rejection but, instead, is critical for the induction of long-term allograft acceptance. The in vivo mechanisms-by which endogenous IFN-y regulates the alloimmune response and thus facilitates the induction of long-term allograft survival are not known. Methods. We examined long-term cardiac and skin allograft ... إقراء المزيد