Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt



Publications Which contain the keyword: Estradiol

2018-09-08 12:25:36 Keywords 2005, chronic nitric oxide, cardiovascular, renal, Estradiol,
Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition
ABSTRACT: Our previous studies in rodent models of nephropathy demonstrate that 2-hydroxyestradiol (2HE), an estradiol metabolite with little estrogenic activity, exerts renoprotective effects. In vivo, 2HE is readily converted to 2-methoxyestradiol (2ME), a major estradiol metabolite with no estrogenic activity. The goal of this study was to determine whether 2ME has renal and cardiovascular protective effects in vivo. First, the ... Read more

2018-09-08 12:33:10 Keywords Estradiol, monocrotaline, pulmonary hypertension, rats,
Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats
ABSTRACT: Pulmonary arterial hypertension (PH) is a deadly disease characterized by pulmonary arterial vasoconstriction and hypertension, pulmonary vasculature remodeling, and right ventricular hypertrophy. Our previous in vivo studies, performed in several models of cardiac, vascular, and/or renal injury, suggest that the metabolites of 17beta-estradiol may inhibit vascular and cardiac remodeling. The goal of this study was to determine whether 2-methoxyestradiol ... Read more

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