INTRODUCTION: Carbon tetrachloride (CCl4) causes hepatic injury, the period of repair of hepatocytes injured by CCl4 and signaling proteins intrinsic to this period were examined. A 30 kDa polypeptide detected by both RT-PCR and Western blott analysis using anti-galectin-3 antibody in livers from mice 48 to 96 h after administration of a single dose of CCl4 was identified as galectin-3 ... Read more

PURPOSE: Galectin-3, a beta-galactoside-binding animal lectin is amultifunctional protein, which regulates cell growth, cell adhesion, cellproliferation, angiogenesis, and apoptosis, and in turn contributes totumorigenesis and metastasis. The aim of this study was to clarify the role orrelated mechanisms of galectin-3 in lung carcinogenesis. METHODS: Weadministrated 4-(methylnitrosamino)-1-(3-pyridyle)-1-butanone (NNK), a powerful chemical carcinogen into galectin-3 wild-type (gal3+/+) and galectin-3 knock-out (gal3-/-) CD1 ... Read more