Objectives: To study the prevalence and patterns ofY-chromosome microdeletions in infertile men from Upper Egypt and to determine the relationship between Y-chromosome microdeletions with clinical and laboratory findings in these patients. Design: Cross-sectional study. Patients: Infertile men (n = 210) and a control group of fertile men with normal semen analysis (n = 30). Methods: Clinical evaluation, standard semen analysis ... إقراء المزيد

OBJECTIVE: To examine levels of sperm DNA damage and oxidative stress (OS) in infertile men with varicocele. DESIGN: Prospective controlled study. SETTING: Male infertility clinic, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio. PATIENT(S): Thirty-one infertility patients and 16 fertile controls. INTERVENTION(S): Sperm DNA fragmentation index (DFI), levels of seminal reactive oxygen species (ROS), and total antioxidant capacity (TAC) were ... إقراء المزيد

OBJECTIVE: To examine the effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. DESIGN: Prospective study. SETTING: Infertility clinic at a tertiary care academic institution. PATIENT(S): Ninety-two infertile men with normal female partners. Sixteen fertile donors served as the control group. INTERVENTION(S): Standard semen analysis and assessment of levels ... إقراء المزيد

OBJECTIVE: To evaluate levels of sperm nuclear DNA damage in infertile men with normal and abnormal standard semen parameters. DESIGN: Prospective study. SETTING: Male infertility clinic. PATIENT(S): Ninety-two men seeking infertility treatment and 16 fertile volunteers. INTERVENTION(S): Standard semen analysis was performed according to the World Health Organization guidelines. MAIN OUTCOME MEASURE(S): Sperm DNA damage was assessed by sperm chromatin ... إقراء المزيد

OBJECTIVE: To investigate the role of increased seminal leukocytes in enhancing reactive oxygen species (ROS) production by human spermatozoa. DESIGN: A prospective study. SETTING: Male infertility clinic. PATIENT(S): Forty-eight infertile men. INTERVENTION(S): Standard semen analysis. Assessment of sperm nuclear DNA damage by sperm chromatin structure assay. Incubation of spermatozoa from nonleukocytospermic samples with blood neutrophils. MAIN OUTCOME MEASURE(S): Spontaneous and ... إقراء المزيد

OBJECTIVES: To study the prevalence and patterns of Y-chromosome microdeletions in infertile men from Upper Egypt and to determine the relationship between Y-chromosome microdeletions with clinical and laboratory findings in these patients. DESIGN: Cross-sectional study. PATIENTS: Infertile men (n = 210) and a control group of fertile men with normal semen analysis (n = 30). METHODS: Clinical evaluation, standard semen ... إقراء المزيد