[Background] Cytotoxic T lymphocytes (CTLs) specific to hematopoietic stem cells (HSCs) are thought to play an important role in the development of acquired aplastic anemia (AA). The presence of HLA class I allele-lacking leukocytes as a result of 6pLOH or allelic mutations in about 25% of AA patients strongly suggests that CTLs specific to antigens presented by the specific HLA ... Read more

Leukocytes lacking HLA class I alleles derived from hematopoietic stem/proge nitor cells (HSPCs) that undergo copy number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in patients with aplastic anemia (AA), but the precise mechanisms u nderlying clonal hematopoiesis by such HLA(-) HSPCs remain unknown. To addre ss this ... Read more

Leukocytes lacking HLA class I alleles derived from hematopoietic stem/proge nitor cells (HSPCs) that undergo copy number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations are often detected in patients with aplastic anemia (AA), but the precise mechanisms u nderlying clonal hematopoiesis by such HLA(-) HSPCs remain unknown. To addre ss this ... Read more