_ABSTRACT_ INTRODUCTION: Breast cancer (BC) is most common cancer site in women worldwide. The CA 15-3 is tumor associated antigen which detects soluble forms of MUC-1 protein. In normal breast tissue MUC-1 is expressed in the duct and acini, but with neoplastic transformation normal cell polarization and tissue architecture is disrupted leading to shedding of MUC-1 in the blood, where ... Read more

INTRODUCTION: Breast cancer (BC) is most common cancer site in women worldwide. The CA 15-3 is tumor associated antigen which detects soluble forms of MUC-1 protein. In normal breast tissue MUC-1 is expressed in the duct and acini, but with neoplastic transformation normal cell polarization and tissue architecture is disrupted leading to shedding of MUC-1 in the blood, where it ... Read more