Ghada Galal

Professor - Head of Tropical Medicine and Gastroenterology Department

Faculty of medicine

Address: Sohag, Egypt



Publications Which contain the keyword: Anticancer

2020-03-19 10:52:40 Keywords DNA, Anticancer, Drug, Intercalation, Minor Grooving, Cisplatin,
DNA Interaction of Drug Molecules for Cancer Treatment
The deoxyribonucleic acid (DNA) is the molecule of life that controls all the chemical changes that take place in cells. It is the molecular target for many of the drugs that are used in cancer therapeutics, and is viewed as a non-specific target of cytotoxic agents. The interaction of drugs with DNA is among the most important aspects of biological ... Read more

Design and nonlinear optical properties (NLO) using DFT approach of new chelates for DNA interaction, antimicrobial, anticancer activities and molecular docking studies
In recent years, metals based antitumor complexes have played a vital role in chemotherapy. Therefore, in this study, some new imine Cr(III), VO(II) and Ni(II) complexes incorporating ESAP imine ligand (2-Ethoxy-6-((2-hydroxy-phenylimino)-methyl)-phenol were designed and synthesized. The investigated complexes were fully characterized by micro analysis, infrared, electronic spectra, thermal analysis(TGA), conductivity as well as magnetic susceptibility measurements. Moreover, the stability constants ... Read more

DNA interaction, antimicrobial, anticancer activities and molecular docking study of some new VO(II), Cr(III), Mn(II) and Ni(II) mononuclear chelates encompassing quaridentate imine ligand
The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, 1H NMR and 13C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, UV–vis and ... Read more

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